Effects of dexrazoxane on doxorubicin-related cardiotoxicity and second malignant neoplasms in children with osteosarcoma: a report from the Children’s Oncology Group

Table 6 Cardiac and NT-proBNP Measurements

Prediction Factor, Model	P ^a
Left Ventricular End-Diastolic Dimension Z-Scores
Univariate Model
Sex	0.04
Final Model
Assessment Point^b	0.77
Sex²	0.74
Assessment Point* Sex Interaction Term	< 0.01
Male Slope^c	0.02
Female Slope^c	0.02
NT pro-BNP, Both Studies Combined
Sex	0.02
NT pro-BNP, P9754
Univariate Models
Assessment Point	0.02
Sex	0.02
Final Model
Assessment Point	< 0.01
Sex	< 0.01
Assessment Point * Sex Interaction Term^d	0.59
NT pro-BNP, AOST0121^e
Final Model
Assessment Point^f	0.05
Sex	0.03
Assessment Point * Sex Interaction Term	0.03
Male Slope^c	0.03
Female Slope^c,f	0.08

^aAll P-value are Type 3 p-values from models produced by Proc Mixed in SAS 9.4, unless otherwise specified
^bThe main effects in the final model were not significant, but were kept because their interaction term was significant
^cP-value obtained by a linear hypothesis H0: Slope = 0 using Proc Mixed in SAS 9.4
^dThe interaction term for assessment point and sex was not found to be significant and was dropped from the final model
^eNeither assessment point nor sex were significant in their respective univariate models
^fMarginally significant

ISSN: 2057-3804