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Fig. 3 | Cardio-Oncology

Fig. 3

From: 14,15-Dihydroxyeicosatrienoic acid, a soluble epoxide hydrolase metabolite in blood, is a predictor of anthracycline-induced cardiotoxicity – a hypothesis generating study

Fig. 3

DOX treatment induced 14,15-DHET expression in culture media of H9c2 rat cardiomyocytes. Cells were collected at 2 h, 6 h and 24 h with 2 h pre-treatment of DMSO (0.01%) (Control) or 1 µM DOX dissolved in DMSO (0.01%). A Levels of 14,15-DHET in culture media of H9c2 cardiomyocytes treated for 60 min with 0, 1 and 5 µM 14,15-EET. B Levels of 14,15-DHET in cell media measured by ELISA. Results were expressed as mean ± SD. *p < 0.05 and **p < 0.01 compared to cells not treated with 14,15-EET or DOX using an independent T-test. The assays were performed in two replications using 4 plating for each replication

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Cardio-Oncology

ISSN: 2057-3804

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