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Table 3 Echocardiographic data

From: Long-term cardiac effects of modern treatment for Hodgkin’s lymphoma

 

AC + MRT (n = 132)

AC alone (n = 114)

Controls (n = 58)

p-value (ANOVA)

p-value AC + MRT vs. AC alone

p-value AC + MRT vs. controls

p-value AC alone vs. controls

Morphology

LA volume, mL/m2

25 ± 6

27 ± 8

29 ± 7

0.016

0.56

0.012

0.31

IVSd, mm

8.8 ± 2.0

9.1 ± 1.8

9.2 ± 1.8

0.33

0.74

0.57

1.00

LVIDd, mm

47 ± 6

50 ± 5

49 ± 6

< 0.001

< 0.001

0.027

0.92

LVPWd, mm

7.8 ± 1.4

8.2 ± 1.3

8.3 ± 1.4

0.012

0.043

0.035

1.00

LV Mass, g/m2

67 ± 17

76 ± 18

76 ± 18

0.002

0.004

0.013

1.00

3D LV EDV, mL/m2

60 ± 9

64 ± 10

65 ± 10

0.012

0.09

0.015

1.00

3D LV ESV, mL/m2

25 ± 6

28 ± 6

27 ± 5

0.06

0.06

0.45

1.00

RA area, cm2/m2

16 ± 3

17 ± 3

17 ± 3

0.06

0.15

0.14

1.00

RV end-diastolic area, cm2/m2

9.3 ± 1.5

9.6 ± 1.7

9.9 ± 1.6

0.18

0.05

0.34

1.00

RV end-systolic area, cm2/m2

5.6 ± 1.1

6.0 ± 1.1

5.8 ± 1.0

0.11

0.020

0.85

0.29

Systolic function

3D LV EF, %

58 ± 5

57 ± 5

59 ± 4

0.13

1.00

0.32

0.15

3D LV SI, mL/m2

35 ± 5

36 ± 6

39 ± 6

0.004

0.49

0.002

0.14

LV GLS, %

19.3 ± 2.5

20.2 ± 2.6

20.8 ± 2.0

< 0.001

0.034

< 0.001

0.34

RV FAC, %

40 ± 7

39 ± 6

41 ± 7

0.28

0.81

1.00

0.39

TAPSE, mm

22 ± 3

22 ± 3

24 ± 3

0.001

1.00

0.002

0.004

Diastolic function

Mitral E velocity, cm/sec

67 ± 18

63 ± 15

65 ± 14

0.13

0.13

1.00

1.00

Mitral A velocity, cm/sec

60 ± 16

54 ± 14

51 ± 15

< 0.001

0.18

0.001

0.56

Mitral E/A-ratio

1.2 ± 0.4

1.2 ± 0.4

1.4 ± 0.4

0.009

0.92

0.007

0.08

Mitral DT, ms

175 ± 47

187 ± 52

161 ± 46

0.005

0.22

0.22

0.004

E/e’-ratio

7.7 ± 2.4

7.1 ± 2.8

6.9 ± 1.8

0.06

0.20

0.11

1.00

TR velocity, m/s

23 ± 3

23 ± 3

23 ± 2

0.99

1.00

1.00

1.00

  1. Data expressed as mean ± SD for parametric data and median (IQR) for non-parametric data. P-values derived from simple one-way ANOVA for continual, parametric data and Kruskal-Wallis one-way ANOVA for continual, non-parametric data. Comparison between individual groups performed with the Bonferonni correction for multiple comparisons
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Cardio-Oncology

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